Nevertheless, IBS is the most common cause of gastrointestinal referral and accounts for frequent absenteeism from work and impaired quality of life. Young women are affected 2–3 times more often than men. Coexisting conditions, such as non-ulcer dyspepsia, chronic fatigue syndrome, dysmenorrhoea and fibromyalgia, are common. Between 5 and 10% of patients have a history of physical or sexual abuse.

The cause of IBS is incompletely understood but bio-psychosocial factors are thought to play an important role, along with luminal factors, such as diet and the gut microbiota. For this making diagnosis become tough for physicians.

According to The Rome Foundation–

New diagnostic criteria: “Rome IV Criteria” for IBS

Recurrent abdominal pain at least 1 day per week associated with two or more of the following –

• Related to defecation.
• Onset associated with a change in the frequency of stool.
• Onset associated with a change in the form of stool.

Rome IV expanded upon this concept with an agreed-upon definition: Disorders of gut-brain interaction. These disorders are classified by GI symptoms related to any combination of:

• Motility disturbance
• Visceral hypersensitivity
• Altered mucosal and immune function
• Altered gut microbiota
• Altered central nervous system (CNS) processing

This definition is most consistent with our evolving understanding of multiple pathophysiological processes that, in part or together, determine the symptom features that characterize the Rome classification of disorders.

IBS subtypes:

Subtyping based only on when stools are abnormal consistency in the absence of therapy.

Current subtypes includes-

1. IBS – A [19-49%] (Alternating IBS),
2. IBS – C [19-44%] (IBS with Constipation) and
3. IBS – D [15-36%] (IBS with Diarrhoea)
4. IBS – U (unclassified IBS)

Proportions of patients in each subgroup stable over time but-

• 75% will experience a change in subgroup over time.
• More likely to transition to IBS-C than to IBS-D.
• Transition from IBS-C to IBS-D in less than a third of patients over a year.

Difficulties in diagnosing IBS:

Common comorbidities in IBS-

• Major depression
• Fibromyalgia
• Chronic fatigue syndrome
• Anxiety
• TMJ disorder
• Chronic pelvic pain
• Painful bladder syndrome/Intestinal cystitis
• Somatoform disorders

Alarm features in patient with suspected IBS:

• Onset of symptoms after age 50
• GI bleeding or Iron deficiency anemia
• Nocturnal diarrhoea
• Weight loss
• Family history of organic GI disease (Colorectal cancer, IBD, Celiac disease)

Biomarkers of IBS:

1. Rule out organic diseases that mimic IBS: Cancer, IBD/microscopic colitis, SIBO, Celiac disease, BAM, Food intolerance.
2. Rule in IBS: Biomarker panels based upon abnormalities in pathophysiology (serotonin, permeability, immune activation, etc.). Biomarker based upon prolonged response to enteric infection (anti-CdtB & vinculin antibody).

IBS vs Microscopic colitis:

Favors IBS-

1. Meal related diarrhoea.
2. Intermittent symptoms.
3. Longstanding symptoms.
4. Symptoms with stress.
5. Family history of IBS.

Favors Microscopic colitis-

1. Nocturnal diarrhoea.
2. Unrelenting symptoms.
3. Short symptom duration.
4. New drug in last 1-3 months.
5. Other autoimmuno disorders.

Celiac disease in Patients with IBS symptoms

Breath testing for SIBO in IBS:

• Breath tests are not validated to accurately detect SIBO.
• There is insufficient evidence to recommend lactulose or glucose breath tests to identify SIBO in patients with IBS.

New diagnoses in Rome IV

1) Reflux hypersensitivity syndrome-

• Heartburn or chest pain with normal endoscopy.
• Reflux triggers symptoms despite normal acid exposure.

2) Cannabinoid hyperemesis syndrome-

• Steriotypical vomiting similar to cyclic vomiting syndrome occurring with excessive cannabis use and symptoms.
• Relieved after discontinution.

3) Opioid induced constipation-

• Development or worsening of constipation symptoms ( hard or infrequent stools, straining, incomplete evacuation) when taking opioids.

4) Narcotic bowel syndrome-

• Progressive and paradoxical increase in abdominal pain despite continued or escalating dosages of opioids prescribed to relieve pain.
• Improves with detoxification.

After reading that, It become very easy to understood and acceptable to clinicians, academicians, regulatory agencies, the pharmaceutical industry, and to patients.

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